A Closer Look at Beta 2-Microglobulin (B2M)

Posted by sleepyguy in Prescription Sleep Medicine on February 17th, 2011

In all people, there is a physiological construct called the “blood/brain barrier.” Over the last several years there has been a lot of interest in using Beta 2-Microglobulin, or B2M, to gain a better understanding for whether or not there has been an improvement in the functioning of that blood/brain barrier. This has mainly come about as a result of the need to examine what scientists and health professionals refer to as brain toxicity and also the detoxification process within the brain.

There has been a growing interest in the issue of toxicity and detoxification due to an understanding of how B2M might be able to attach itself to certain metals and heavy metals such as mercury and free iron in the brain, allowing them to be neutralized and then shuttled out of the brain and the surrounding liquids cushioning the brain from possible injury.

One reason the possibility of using B2M as a method for assessing improvement in the blood/brain barrier and the ability to scavenge out such heavy metals is that Beta 2 Microglobulin seems to be so ubiquitous within certain areas of the blood/brain barrier and a person’s cerebrospinal fluid that bathes that same person’s brain and spinal column.

When B2M is noted in high levels in relation to other proteins within that blood/brain barrier and within the cerebral spinal fluid it is reasonable to assume that there could be oxidative (sometimes known as “rusting”) damage to the blood/brain barrier itself. It can also indicate that there might be a flaw in the proper function of that same barrier due to overexposure to some sort of heavy metal like mercury.

For those not up on what health professionals and scientists refer to as the “blood/brain barrier,” it is something that acts like a figurative sort of wall that prevents the passage of both acids and bases that could lead to immediate damage to the brain from even very slight pH changes to the liquid surrounding the brain. It is well known that even very slight changes to a body’s pH could have serious implications to health.

This is why being able to use something like B2M to assess possible issues with toxic levels of heavy metals that could affect the brain’s pH is so important. Scientists and health professionals know that it is extremely important that the brain be kept as free as possible from contamination by toxic agents such as mercury. Once found in numerous home thermostats and played with my children for years and years, mercury poisoning is insidious and potentially lethal.

Additionally, B2M assessment can lead to processes aimed preventing such metals from breaking out into certain organs of the body where these metals would also have to be metabolized before excretion from the urine. Naturally, such metals can do eventual damage to organs like the kidneys and deliver. In fact, there is no end to the havoc heavy metal poisoning can do to a human over a period of time.

People suffering from overexposure to mercury and other heavy metals that adversely impact the blood/brain barrier and then the brain itself may often be thought to be suffering from other medical conditions, which brain toxicity can mimic. This is unfortunate because the underlying issues are therefore never corrected in the brain can be adversely impacted permanently. In the worst cases such toxicity will lead to death.

Fortunately for all, a clear eyed understanding of the implications surrounding elevated levels of B2M is well understood by many medical professionals nowadays. In the past, as late as just a decade or so ago, this was not always the case and a person could go along continuing to be exposed to heavy metals or the accumulation of free irons, which eventually would lead to certain neurodegenerative disorders, especially the most well-known, Parkinson’s Disease.

Today, it is more important than ever that person’s demonstrating what might at first appear to be neurological deficit type disorders resembling Parkinson’s be fully evaluated for elevated levels of B2M in an effort to correctly diagnose the issue, itch might just be a heavy metal has wormed its way through the blood/brain barrier.

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